Pubblicazioni Selezionate

Ambrogio C*, Köhler J, Zhou ZW, Wang H, Paranal R, Li J, Capelletti M, Caffarra C, Li S, Lv Q, Gondi S, Hunter JC, Lu J, Chiarle R, Santamaría D, Westover KD, Jänne PA*. KRAS dimerization impacts MEK inhibitor sensitivity and oncogenic activity of mutant KRAS. Cell. 2018 Jan 4. *Co-corresponding author. PMID: 29336889.
Ambrogio C*, Gómez-López G, Falcone M, Villanueva A, Crosetto N, Blasco R, Sánchez-Céspedes M, Ren X, Wang Z, Ding K, Serrano M, Hidalgo M, Santamaría D*, Barbacid M*. Combined inhibition of Ddr1 and Notch signaling as an effective therapeutic strategy for K-Ras-driven/p53-null lung adenocarcinomas. Nat Med. 2016 Feb 8. *Co-corresponding author. PMID: 26855149.
Nieto P, Ambrogio C, de Esteban L, Gómez-López G, Blasco MT, Yao Z, Marais R, Rosen N, Chiarle R, Pisano DG, Barbacid M, Santamaría D. A B-Raf kinase inactive mutant induces lung adenocarcinoma. Nature. 2017 Aug 2. PMID: 28783725.
Ambrogio C*, Barbacid M, Santamaría D*. In vivo oncogenic conflict triggered by co-existing KRAS and EGFR activating mutations in lung adenocarcinoma. Oncogene. 2016 Oct 24. *Co-corresponding author. PMID: 27775074.
Choudhari R, Minero VG, Menotti M, Pulito R, Brakebusch C, Compagno M, Voena C, Ambrogio C*, Chiarle R*. Non redundant roles for Cdc42 and Rac1 in ALK-rearranged lymphoma. Blood. 2016 Jan 8. *Co-last author. PMID: 26747246.
Wang H, Lv Q, Xu Y, Cai Z, Zheng J, Chen X, Dai Y, Jänne PA, Ambrogio C* and Köhler J*. An integrative pharmacogenomics analysis identifies CK2 alpha as a promising therapeutic target in KRAS(G12C) mutant lung cancer. EBioMedicine. 2019 Nov. *Co-last author. PMID: 31668570
Nokin MJ, Darbo E, Travert C, Drogat B, Lacouture A, San José S, Cabrera N, Turcq B, Prouzet-Mauleon V, Falcone M, Villanueva A, Wang H, Herfs M, Mosteiro M, Jänne PA, Pujol JL, Maraver A, Barbacid M, Nadal E, Santamaría D and Ambrogio C. Inhibition of DDR1 enhances in vivo chemosensitivity in KRAS-mutant lung adenocarcinoma. JCI Insights. 2020 Aug 6.
Venkatesh P Mysore^*, Zhi-Wei Zhou^*, Chiara Ambrogio^*, Lianbo L, Jonas N Kapp , Chunya Lu, Qi Wang, Maxwell R Tucker, Jeffrey J Okoro, Gabriela Nagy-Davidescu, Xiaochen Bai, Andreas Plückthun, Pasi A Jänne, Kenneth D Westover, Yibing Shan, David E Shaw. A structural model of a Ras-Raf signalosome. Nat Struct Mol Biol. 2020 Oct 21. * Co-First Author.
Ricciuti B, Son J, Okoro JJ, Wang X, Paranal R, Wang H, Eum Y, Lin M, Haikala HM, Li J, Xu Y, Alessi JV, Chhoeu C, Mira A, Patrucco E, Redig AJ, Köhler J, Richard E, Nokin MJ, Santamaria D, Gokhale PC, Awad MM, Jänne PA, Ambrogio C. Comparative analysis and isoform-specific therapeutic vulnerabilities of KRAS mutations in non-small cell lung cancer. Clinical Cancer Research. 2022 Feb 1.